Maximum dose: for adults for IV injections the loading dose is 100 mg, in a subsequent drop infusion it is 2 mg / min when IM administration - 300 mg (about 4.5 mg / kg) for 1 h.ДЇor children in case of reintroduction the loading dose every 5 minutes, the total dose is 3 mg / kg by continuous intravenous infusion (usually following the introduction of a loading dose) - 50 mg / kg / min. IM is introduced to 2-4 mg / kg, if necessary, repeated administration is possible through 60-90 minutes.ДЇor children with IV injection loading dose - 1 mg / kg, if necessary, it may be repeated administration in 5 min.ДЇor continuous intravenous infusion (usually following the introduction of a loading dose) - 20-30 mg / kg / min.ДЇor use in surgical and obstetric practice, dentistry, ENT practice, dosing regimen set individually, depending on the evidence, the clinical situation and used the dosage form. If necessary, against the background of drop infusions can repeat IV jet injection of Trigon Rectal 40 mg after 10 minutes after the first loading dose. Drip infusion can be carried out within 24-36 hours. Then immediately transferred to drip infusion at a rate of 20-55 mg / kg / min. In cardiological practice: treatment and prevention of ventricular arrhythmias (extrasystoles, tachycardia, atrial flutter, atrial fibrillation), including in acute myocardial infarction, implantation of artificial pacemaker in the glycoside intoxication, narcosis.ДЄnaesthesia: terminal, infiltration, conduction, spinal (epidural) anesthesia in surgery, obstetrics and gynecology, urology, ophthalmology, dentistry, otolaryngology, blockade of peripheral nerves and ganglion.ДЄs an anti-arrhythmic medicine for adult with the introduction of a loading dose by IV - 1-2 mg / kg over 3-4 minutes the average single dose is 80 mg. Trigon Rectal (Lidocaine) excreted by the kidneys as metabolites, 10% unchanged. In general T 1/2 depends on the dose is 1-2 hours and can grow up to 3 hours or more during prolonged intravenous infusion (over 24 h). T 1/2 tends to be two phases with the phase distribution of 9.7 min. Trigon Rectal (Lidocaine) metabolized mainly in the liver with the formation of active metabolites, that may contribute to the manifestation of the therapeutic and toxic effects, especially after the infusion for 24 hours or more. The protein binding depends on the concentration of the active substance in the plasma and is 60-80%. The distribution is rapid, Vd is about 1 L/kg (in patients with heart failure it is below). Trigon Rectal (Lidocaine) causes all kinds of local anesthesia: a terminal, infiltration and wires.ДЄfter IM administration absorption of Trigon Rectal (Lidocaine) is almost complete. When applied as an antiarrhythmic agent in IV injection it begin to act in 45-90 seconds, the duration of action is 10-20 minutes for IM administration the onset of action is in 5-15 minutes, the duration - 60-90 minutes. When used in the medium therapeutic doses virtually no effect on myocardial contractility and slows AV-conduction. In this case, Trigon Rectal (Lidocaine) inhibits electrical activity in depolarized, arrhythmogenic sites, but minimally affects the electrical activity of normal tissues. This drug reduces the duration of the action potential and effective refractory period in Purkinje fibers, inhibits their automaticity. Trigon Rectal (Lidocaine) causes a blockade of sodium channels of excitable membranes of neurons and the membrane of cardiomyocytes. This medication has membrane stabilizing activity. Trigon Rectal is an antiarrhythmic agent of class IB, local anesthetic, a derivative of acetanilide.

Trigan vs